First metatarsal pain by pressing is usually caused by external force injury, long-term exertion or by diseases, which can be continued to be treated by drugs and surgical methods. 1. External injury: most of the metatarsal pain is caused by external injury to the metatarsophalangeal joints or prolonged exposure to cold. In daily life, patients are under the environment of air-conditioning fan for a long time or take cold shower for a long time, which will change the internal environment of patients and cause metatarsal pain due to cold. Patients can use some anti-inflammatory and analgesic drugs for symptomatic treatment, such as Loxoprofen sodium. 2. Long-term fatigue: Many patients suffer from long-term fatigue, standing and walking for a long time, which can cause local joints to be compressed, and the soft tissues attached to the bones and joints are repeatedly pulled, which can lead to exudation of prostaglandins and metatarsalgia. The patient can be closed or apply the small needle knife to loosen the method for corresponding treatment. 3. Disease: Patients suffering from suppurative infectious diseases can cause local soft tissue damage, which in turn causes changes in the local internal environment, resulting in metatarsalgia. Patients should be treated with anti-inflammatory, anti-swelling, analgesic, and fracture healing medications, and surgical intervention may be required for some cases of very severe inflammation or severe osteoporosis or osteomalacia. Patients should also pay attention to keep warm to avoid the affected area being stimulated by cold air, which may cause other sequelae. It is also effective in preventing the body from experiencing cold symptoms, avoiding the invasion of bacteria, and also preventing other complications.