Many diabetics are very afraid of insulin once they hear that they have to take it. On the one hand, they are afraid of the pain and trouble, and on the other hand, they think that insulin injection is like drug addiction, once they use it, they will become addicted and can never leave it again. Therefore, some patients are very resistant to insulin injections, in fact, this is completely wrong insulin, the following I will give insulin “vindication”. Humans have been using insulin to treat diabetes for more than 80 years. Before the invention of insulin diabetes is almost a terminal disease, especially adolescent patients not only growth and development stalled and often die in the ketoacidosis attack. In 1922, scientists discovered that there is a substance in the pancreas that can lower blood sugar, and named it “insulin”. Since then, the treatment of diabetes has turned a new page. In the 1980s, genetically recombinant human insulin was produced, which is identical to human insulin, reducing side effects and improving efficacy. Since then, insulin analogues have been invented, which have benefited more and more patients because of their fast onset of action, strong effect and ease of use. Insulin is the most effective and powerful weapon used to treat diabetes, and good glycemic control is the key to delaying and reducing complications. It is well known that insulin is necessary for the treatment of type 1 diabetes, and it is also suitable for patients with type 2 diabetes whose blood glucose is not well controlled by oral hypoglycemic drugs, and for some newly discovered patients with type 2 diabetes who have high blood glucose, intensive treatment with insulin for a period of time is also advocated to enable better repair and remission of their own islet function, so that insulin can also be reduced or even stopped and replaced by oral medication Of course, insulin is not perfect. First, subcutaneous injections can be inconvenient and painful. In fact, with the advancement of insulin dosage forms, most patients can control their blood glucose by injecting 1-2 times a day, which is relatively convenient. Moreover, the current injection needles are so fine and sharp that little pain is felt if the needles are changed in a timely manner as prescribed. Secondly, hypoglycemic reaction, which is also a concern for some patients, we can learn and improve our knowledge in this area, and avoid serious hypoglycemia by detecting blood glucose in time. Of course, there is another pitfall of insulin therapy, which is weight gain. And after some patients are on insulin, they add meals many times because they are worried about hypoglycemia, which eventually leads to weight gain. Therefore, insulin therapy should be accompanied by diet control, increased exercise, monitoring of weight change and timely adjustment of dosage. Therefore, as long as insulin is properly understood and used reasonably, it is still very safe and definitely does not produce dependence, and it is a powerful weapon to control diabetes at present.