40-year-old woman lack of luteinizing hormone can be supplemented with luteinizing hormone therapy, gonadotropin therapy and so on, as prescribed by the doctor. 1. Supplemental luteinizing hormone treatment: 40-year-old women due to luteal insufficiency resulting in a decrease in luteinizing hormone secretion, you can comply with the doctor’s instructions through exogenous oral or intramuscular injection of luteinizing hormone direct supplementation, so that the body’s luteinizing hormone to reach the normal physiological level. 2. Gonadotropin therapy: Luteal insufficiency can be caused by insufficient secretion of gonadotropins by the pituitary gland, resulting in a lack of luteinizing hormone. Gonadotropin supplementation can stimulate the corpus luteum to secrete more progesterone, thus increasing the level of progesterone in the body. 40-year-old woman lack of luteinizing hormone should go to the hospital in a timely manner, under the guidance of the doctor to use the appropriate medication, do not blindly use their own medication, so as not to produce adverse effects.