Hepatocellular carcinoma is a type of primary liver cancer, which is the most common type of liver cancer. 1. Clinical manifestations: Early hepatocellular carcinoma has inconspicuous clinical manifestations. Pain in liver area is the most common and main symptom; digestive symptoms include loss of appetite, abdominal distension, nausea, vomiting, etc.; patients with advanced stage may have obvious fatigue, emaciation, etc.; the most common sign of middle and advanced hepatocellular carcinoma is enlarged liver; jaundice is also common in the patients; patients with advanced stage may have ascites, which leads to abdominal distension, and ascites is grass-green color or bloody ascites. 2. Means of examination: serological examination shows that the index of alpha-fetoprotein of the patient rises, in addition, there may be elevated tumor markers such as γ glutamyl transpeptidase and α1 antitrypsin. In liver function tests, serum bilirubin, albumin/globulin ratio, glutamic transaminase and other indicators have diagnostic value; in addition, ultrasound, CT, MRI and other imaging means can be used to help diagnosis. Liver puncture biopsy can obtain accurate pathologic diagnosis. 3. Treatment: hepatectomy is the first choice of liver cancer treatment in China. There are also surgical therapies such as palliative tumor resection, hepatic artery ligation, chemoembolization of hepatic artery, intraoperative condensation or thermal coagulation therapy. Molecular targeted drug therapy is available, and commonly used drugs are sorafenib and regorafenib. Commonly used drugs for chemotherapy include doxorubicin, cyclophosphamide, fluorouracil, etc. Radiotherapy includes internal radiation therapy and external radiation therapy and other therapies. For patients diagnosed with liver cancer, they should go to the relevant departments of regular hospitals as soon as possible and under the guidance of professional physicians to avoid delaying the condition.