Pemetrexed is a more effective drug for the treatment of lung adenocarcinoma, but the preferred treatment option for lung adenocarcinoma is surgery. Pemetrexed is the first-line chemotherapy regimen for the treatment of lung adenocarcinoma and should be used under the guidance of an oncologist. Pemetrexed is more effective than other chemotherapy drugs. In general, combining chemotherapy with other drugs is more effective than using pemetrexed alone. Although pemetrexed is a more effective drug in treating lung adenocarcinoma, the effect of drug treatment of lung adenocarcinoma is not as good as that of surgical treatment. Surgical resection is the main treatment for most types of lung cancer, and it should be preferred as much as possible when the classification of the lung cancer, the basic condition of the body and the indexes of the examination meet the standard of surgery. Lung adenocarcinoma should be selected by doctors according to the comprehensive judgment of examination results.