Bartholin’s sign is not a disease, but a pathological reflex, which is a reflex that does not exist in normal people. The operation of Bartholomew’s sign is to take the patient in a supine position with the lower limb straight, the examiner holds the ankle with one hand, the other hand uses a bamboo stick to scratch along the lateral edge of the sole of the foot from back to front to the root of the little toe, then turn to the inside, the normal performance of the toe to the metatarsal plane flexion, that is, the Bartholomew’s sign negative. If the bunion is dorsiflexed and the remaining four toes are fan-shaped, it is called positive Bartholomew’s sign, which is mostly seen in cerebrovascular accidents and spinal cord transection injuries. The positive Bartholomew’s sign is mainly caused by the loss of inhibition of the brain stem and spinal cord due to the damage of the pyramidal tract.