Cephalosporin and Archie belong to different kinds of antibiotics with different antimicrobial spectrums, there is no good or bad, clinical mainly according to different clinical symptoms empirically choose different antibiotics with different antimicrobial spectrums, at the same time actively improve the pathogen examination and drug sensitivity test, according to this in order to carry out accurate antibiotic treatment. Cephalosporin antibiotics belong to the β-lactam class, with a broader antibacterial spectrum and better antibacterial effect on bacteria, but with poorer efficacy on atypical pathogens such as mycoplasma and chlamydia. Azithromycin belongs to macrolide antibiotics, covering atypical pathogens such as mycoplasma and chlamydia, but it is more resistant to bacteria. Azithromycin has more gastrointestinal reactions, cephalosporins have more allergic chances than azithromycin, and should not be used by patients with cephalosporin allergy.