The Chinese name of MTX is methotrexate. A small amount of pelvic fluid in a patient with ectopic pregnancy will generally not affect the effect of methotrexate. If the patient has more pelvic fluid, the effect of methotrexate may be poorer, and the possibility of intra-abdominal hemorrhage cannot be ruled out. Methotrexate belongs to the chemotherapeutic drugs, which has the ability to inhibit the proliferation of trophoblast cells and destroy the embryonic villi. Ectopic pregnancy patients treated with methotrexate can make the embryonic tissue fall off, necrosis and absorption. Ectopic pregnancy patients with pelvic effusion, if a small amount of fluid, usually does not affect the therapeutic effect, if the ectopic pregnancy rupture caused by increased bleeding, usually not recommended to use MTX treatment, on the one hand, the effect is poor, on the other hand, there is hemorrhage in the pelvis, it is usually recommended to carry out surgical treatment. The treatment plan for ectopic pregnancy patients needs to be decided according to the patient’s specific situation, and professional gynecologists should be consulted to avoid making decisions on their own, which may affect the prognosis.