Genital herpes can be treated with both internal and external medications. Internal medications are mainly antiviral medications such as acyclovir, valacyclovir, and ganciclovir; topical medications include antiviral creams or ointments; and pain relievers include acetaminophen and ibuprofen. Genital herpes is a sexually transmitted disease caused by herpes simplex virus type II and is mainly transmitted through sexual contact. The principle of treatment is to shorten the course of the disease, prevent secondary bacterial infection and systemic dissemination, and reduce the chance of recurrence and transmission. 1. Systemic drug therapy Antiviral drugs can inhibit the activity of DNA polymerase, thus inhibiting the replication of viral DNA. Representative drugs include acyclovir, valaciclovir, famciclovir and so on. Patients infected with genital herpes for the first time usually need to use the medication for 7 to 10 consecutive days to reduce the replication of the virus. Patients with recurrent genital herpes should be medicated as early as possible, preferably no more than 24 hours after the appearance of blisters. 2. Topical drug treatment is based on antiviral, astringent, drying and preventing secondary infection. 3% acyclovir ointment, 1% penciclovir cream or glycerite lotion can be used; fusidic acid cream and mupirocin ointment can be used for secondary infection. 3. Some genital herpes can cause severe burning or cutting pain, patients can take painkillers under the guidance of the doctor to relieve. For mild to moderate pain, non-steroidal drugs such as aspirin, acetaminophen, and ibuprofen can be used. Painkillers should be prescribed by your doctor and should not be changed or increased on your own. At present, most experts believe that the initial infection of genital herpes, after active treatment, the disappearance of systemic symptoms, skin lesions subside, even if the clinical cure.