Ovarian atrophy is clinically called premature ovarian failure. 39-year-old premature ovarian failure stopped menstruation, the general recommendation of hormone replacement therapy, is the need for long-term medication, but the specific need to be based on the patient’s condition to decide. Premature ovarian failure refers to the loss of normal function of the ovary before the age of 40 years, amenorrhea, infertility, insomnia and other perimenopausal symptoms, can be prescribed appropriate oral estradiol valerate, dydrogesterone and other drugs to regulate the body’s hormone levels, to maintain the menstrual flow. It is necessary to take long-term medication, but the specific need to decide according to the patient’s condition. Because premature ovarian failure is generally incurable, so patients need to go to the hospital in time after the onset of the disease under the guidance of the doctor to carry out reasonable intervention to control the condition, so as not to lead to aggravation of the disease.