Low mood after treatment of heart failure patients is a manifestation of heart failure combined with depression, and its treatment mainly includes exercise, appropriate cognitive therapy, and taking sertraline and other medications as prescribed by the doctor. 1. Exercise: it can significantly improve the symptoms and clinical prognosis of patients with heart failure combined with depression. Among them, aerobic exercise can be the preferred form of exercise to reduce depressive symptoms and prevent the risk of depression. 2. Cognitive-behavioral therapy: Appropriate cognitive therapy can enable heart failure patients to correctly perceive their condition and symptoms, correct incorrect perceptions of the disease and unhealthy behaviors, and help patients re-establish their confidence in recovery and optimistic state of mind. It helps to improve the depression symptoms of heart failure patients. 3. Drug therapy: traditional antidepressants, such as tricyclic antidepressants, escitalopram oxalate, when applied to patients with heart failure combined with depression, the therapeutic effect is not good. Selective pentahydroxytryptamine reuptake inhibitors, such as sertraline, have been shown to be effective in patients with heart failure combined with mild depression. The proportion of patients with heart failure suffering from depressive co-morbidities is about 20% to 30%, and studies have pointed out that heart failure combined with depression significantly increases the lethality and disability of patients, while the reduction of depressive symptoms significantly improves the quality of life of patients with heart failure.