The constant feeling of insects crawling on the body may be caused by pruritus, peripheral neuritis, and vegetative nerve dysfunction. 1. Pruritus: a skin disease that refers to itchy skin, but no primary skin damage. The main manifestation is generalized or localized itching of the skin, which can also be manifested as ant-crawling sensation, burning sensation and other discomforts, with or without dry and flaky skin, scratches, blood scabs and other symptoms. Thus, it is manifested as an old feeling of insects crawling on the body. 2. Peripheral neuritis: it is a general term for multiple peripheral nerve damage caused by various reasons such as infection and poisoning. Its main manifestation is limb sensory impairment, such as burning, pain, numbness, ant crawling sensation, pins and needles sensation and other symptoms, which can be accompanied by motor disorders, such as muscle weakness, hypotonia and so on. It can also lead to a feeling of insects crawling on the body. 3. Phytoneurological dysfunction: caused by over-excitement of some areas of the cerebral cortex. It can also lead to a feeling of crawling insects, usually accompanied by chest tightness, panic, loss of appetite, bloating, dizziness, insomnia, numbness of the limbs, menstrual irregularities and other symptoms. There are many other causes for the feeling of crawling insects on the body, which should be taken seriously, timely consultation, identification of the cause of the disease, and follow the doctor’s advice for further treatment or therapy.