NT-proBNP, also called amino-terminal pro-brain natriuretic peptide, is actually one of the chemical structures of BNP precursors after degradation and can be understood as a metabolite of BNP. It is biologically inactive and occurs in equal amounts with biologically active BNP, and its increased concentration can indirectly reflect the concentration of BNP in the blood, and its long half-life is used to determine whether a recent heart failure event has occurred. BNP is known as natriuretic peptide, which has diuretic and vasodilatory biological effects and is secreted mainly in the ventricles, when the heart is subjected to strain and pressure changes, this substance begins to be secreted with the purpose is to reduce the volume to which the heart is subjected and to reduce the load on the heart. Once this substance is increased in the blood, the heart is in a state of heart failure. However, BNP has a short half-life and does not respond to recent cardiac events as well as NT-proBNP, and the latter is preferred clinically.