Penicillin-allergic patients can choose antibiotics other than penicillin antibiotics such as amoxicillin as the treatment of H. pylori, such as tetracycline, metronidazole, etc., and the medication should be used in accordance with the doctor’s instructions. The eradication treatment of Helicobacter pylori is currently generally recommended quadruple drug therapy, specifically refers to the proton pump inhibitor 1 + bismuth 1 + antibiotics 2, can be cited as rabeprazole + colloidal bismuth pectin + furazolidone + amoxicillin, the course of treatment is generally recommended to be 10 to 14 days. The contraindications of amoxicillin include those who are allergic to penicillin, so those who are allergic to penicillin allergy can replace amoxicillin with other sensitive antibiotics such as tetracycline, metronidazole, clarithromycin and so on. At the end of the treatment course, the drug can be stopped for 1 month and then review the breath test. Specific medication should be under the guidance of a specialist, not unauthorized use of medication.