The blisters on the back of the hands may be caused by herpes zoster, chickenpox, contact dermatitis and other diseases, and need to take medication for the cause. 1. Herpes zoster: blisters on the back of the hand may be caused by herpes zoster, patients can take oral antiviral drugs under the guidance of a doctor, such as acyclovir, vasiclovir and so on. When the pain is obvious, oral gabapentin capsules can be taken to improve the pain. 2. chickenpox: the back of the hand blisters are also considered to be caused by chickenpox, the rash can be generalized, not limited to the back of the hand, the disease has a self-limiting, to the general treatment and symptomatic treatment is given priority to, can follow the doctor’s instructions oral aciclovir, famciclovir and other antiviral drugs. 3. contact dermatitis: the back of the hand long blisters may also be caused by contact dermatitis, the patient can be in the doctor’s guidance of the external use of tretinoin, mometasone furoate ointment and other glucocorticosteroid drugs. Or oral antihistamines, such as loratadine, cetirizine and so on. There are many reasons that lead to blisters on the back of the hand, and it is recommended that patients go to the hospital in a timely manner and undergo a relevant examination, so as to clarify the cause of the disease.