Parkinson’s disease is a common disease of the nervous system in middle-aged and elderly people, the onset is slow and the initial symptoms are often undetected. 1. Resting tremor: Tremor is often the earliest manifestation of the disease, usually starting from the distal end of one side of the upper limb, with the thumb, index finger and middle finger predominantly, manifesting as finger movements like rolling pills or counting banknotes. It then gradually extends to the ipsilateral lower extremity and the contralateral extremity, and in the late stage, it may spread to the jaw, lips, tongue and head. In the early stage of the disease, the patient does not care much about the tremor, which often appears when the fingers or limbs are in a particular position and disappears when the position is changed. Later, the tremor develops only when the limb is at rest, for example, when watching TV or talking with others, the limb suddenly appears to tremble involuntarily, and the tremor decreases or stops when changing position or movement, so it is called resting tremor, which is the most important feature of tremor in Parkinson’s disease. The tremor intensifies when the patient is emotionally excited or nervous, decreases during random movements, and can disappear completely during sleep. It is also sensitive to weather changes. Another characteristic of tremor is its rhythmical nature, with the frequency of the vibrations being 4-7 times per second. This feature can also help us to distinguish other diseases such as chorea, cerebellar disorders, and hyperthyroidism. 2. Muscle rigidity: The limbs and torso of Parkinson’s disease patients usually lose their flexibility and become very stiff. The early stage of the disease mostly starts from one limb. Initially, the movement of one limb feels inflexible and stiff, and gradually worsens, resulting in motor retardation and even difficulty in doing some movements of daily life. If you pick up the patient’s arm or leg and help him to move the joint, you will clearly feel the stiffness of the limb, and it is difficult to move the joint, as if you are bending a lead pipe back and forth. If the affected limb has tremor at the same time, there is a feeling of intermittent pause, like the feeling of two biting gears turning. 3. Motor retardation: In the early stage, due to the tonicity of the upper arm muscles and finger muscles, the patient’s upper limbs are often unable to make fine movements, such as untying shoelaces, buttoning and other movements become much slower than before, or cannot be completed successfully. Writing also gradually becomes difficult, and the handwriting becomes curved and smaller, which is called “small writing disorder”. The facial muscle movements are reduced, the patient rarely blinks, the rotation of the eyes is also reduced, and the expression is dull, as if wearing a mask, called “mask face”. When walking, it is difficult to start, once the step is started, the body leans forward, the center of gravity shifts forward, the pace becomes smaller and faster, and the step cannot be stopped in time, i.e. “panic gait”. During walking, the synergistic swing of the affected upper limb decreases or even disappears; it is difficult to turn around, and it takes several consecutive small broken steps to turn around. Due to the impaired movement of the mouth, tongue, jaw and pharyngeal muscles, the patient is unable to swallow saliva naturally, resulting in profuse salivation. Speech is reduced, and the voice is low and monotonous. In severe cases, this can lead to choking and coughing when eating and drinking. In the advanced stage of the disease, the patient cannot stand by himself after sitting down, cannot turn over by himself after being bedridden, and cannot take care of himself in daily life. 4.Special posture: Although all muscles of the patient’s body can be involved and muscle tone is increased, the flexor muscle tone is higher than the extensor muscle at rest, so the patient has a special posture. (1) Flexion posture: head tilted forward, trunk slightly flexed, upper arm inward, elbow joint bent, wrist slightly extended, metacarpophalangeal joint bent and interphalangeal joint straightened, thumb to palm, hip and knee joints mildly bent. (2) Panic gait. 5, other: (1) mouth, pharyngeal dyskinesia, slow speech; (2) autonomic symptoms: persistent constipation, night sweating, upright hypotension; (3) sebaceous hypersecretion, sebaceous face; (4) psychiatric symptoms: depression, lack of desire, intellectual decline; (5) phytodysfunction phenomena, such as increased saliva and sebaceous secretion, increased or reduced sweat secretion, difficulty excreting large and small stools and upright hypotension. (5) Phenomena of phytodysfunction, such as increased secretion of saliva and sebaceous glands, increased or decreased sweat secretion, difficulty in defecation and upright hypotension. All of the above are clinical manifestations of Parkinson’s disease, which may include one or several, and there are some differences in the degree and form of change.