Urinary ketone bodies with two plus signs suggests comorbid ketosis, and there are two general clinical conditions that can lead to ketosis. One condition is diabetic ketosis. Diabetic patients because of poor glycemic control, accompanied by a lack of insulin in the body, the body can not effectively utilize glucose for energy metabolism, can only carry out the oxidative decomposition of fat in order to ensure the body’s energy needs. This process produces a large number of ketone bodies, which exceed the metabolic capacity of the liver, and the excess is excreted in the urine, producing the phenomenon of urinary ketone bodies plus. This condition is an acute complication of diabetes and requires urgent medical attention. The second condition is starvation ketosis. It is mainly seen in patients who eat poorly for various reasons, or those who lose weight and eat very few carbohydrates, the body does not have sufficient carbohydrates for energy, and the same fat oxidation and decomposition will take place, producing ketone bodies. This kind of ketosis should encourage the patient to eat in time or rehydration, ketone bodies will be eliminated.