Cephalosporins and levofloxacin have their own advantages, depending on the specific pathogen being targeted. If it is a gram-positive coccus, it is likely that both will be effective. However, if the cephalosporin has the 3rd or 4th generation, the antimicrobial spectrum is generally broader, then it is likely to be more effective than levofloxacin. However, if the pathogen is not gram-positive cocci, but some mycoplasma, chlamydia or rickettsia, then cephalosporin is generally ineffective, and only then can levofloxacin be effective. Therefore, in terms of antibacterial spectrum, there are actually advantages of each. If it is used in pregnant women or children, then levofloxacin should not be used. Most cephalosporins can be applied at this time because they may affect the growth and development as well as the bone growth of children. Which one is effective should be clinically dependent on the specific pathogenic bacteria of the infection. Sometimes you need to do a bacterial culture to get the results of the drug sensitivity test to be able to know which antibiotic is more effective.