When I read some books and magazines or browse some websites, I often find reports about magical “scar needles”, but in fact, these so-called scar needles use some common drugs, and there is nothing magical about them. At present, there are many drugs used to treat scarring, and the most common ones used clinically are corticosteroids. In addition, there are peptide growth factors, calcium channel blockers, anti-free radical agents, retinoids, antihistamines, and antineoplastic drugs. It should be recognized that pharmacotherapy is only an organic part of the comprehensive scar treatment and its role should not be overstated, especially for patients with keloids.
Corticosteroids are the most widely used class of drugs in clinical treatment of keloid scars. Adrenocorticosteroids include several categories such as glucocorticoids and salt corticosteroids, among which glucocorticoids have anti-inflammatory, antiviral, and anti-shock functions, and have obvious anti-tissue fibrosis effects; at present, the most effective type of glucocorticoid for anti-keloid scarring is triamcinolone acetonide (triamcinolone acetonide, other common translation names include trimethoprim, It is generally believed that deferensone-A can inhibit the proliferation of fibroblasts, reduce the synthesis of collagen, increase the degradation of collagen, and promote the apoptosis of fibroblasts, thus exerting its effect on the treatment of scarring.
1.Specific method of hormone local injection for scar treatment Generally, you have to come to the hospital first and start the injection treatment after the doctor thinks it is necessary to perform scar hormone injection treatment.
The dose of each injection is 10~40mg, and generally 4~8 times of injection is a course of treatment, with a general interval of 1~2 weeks between two injections. Hormone injection therapy is suitable for patients with relatively small lesions, especially for patients with localized keloids and unsuitable for surgical treatment. Since the injections are given in very small amounts and mainly into the lesion, there are usually no serious side effects; however, side effects have been reported after administration. The main side effects include skin atrophy, pigmentation changes, capillary dilation, local necrosis, and ulceration.
2. Evaluation The main function of applying local medication for pathological scar treatment, especially for keloid, is to improve local pain and itching symptoms, control the continued growth of the lesion, and accelerate the softening of the local scar, which does not eliminate the keloid fundamentally. In addition, for early hyperplastic keloids, hormone injections are more effective and can flatten the hyperplastic tissue, while for hyperplastic keloids with long duration of disease, they can only improve the symptoms.
3. Local injection of drugs plus surgical excision for keloid scars If there are no perfect preoperative and postoperative measures to prevent the proliferation of keloid scars, generally speaking, it is not advisable to treat keloid scars by surgical excision.
Some scholars combine local injections with surgical excision to treat keloids as follows: before surgery, local irradiation of the lesion with hormones is applied until the lesion no longer fades further, then surgical excision of the lesion is performed, and immediately after surgical excision of the scar tissue, injection therapy is administered at the trabecular margin. Then, it is extended to once a month for 3-6 months. The treatment is basically finished.