When acute leukemia has not yet invaded the central nervous system, there is usually no obvious abnormality in cerebrospinal fluid examination; when combined with central nervous system lesions, cerebrospinal fluid may show abnormal manifestations such as elevated pressure and leukocytosis. 1. Acute leukemia is a malignant clonal disease of hematopoietic stem progenitor cells. At the onset of the disease, abnormal primitive and naive cells in the bone marrow proliferate in large numbers and inhibit normal hematopoiesis, which may extensively infiltrate various organs such as liver, spleen and lymph nodes. If acute leukemia does not infiltrate the central nervous system, there is usually no obvious abnormality in the cerebrospinal fluid. 2. When acute leukemia is combined with central nervous system lesions, patients may manifest headache, dizziness, meningeal irritation, convulsions and coma. At this time, cerebrospinal fluid examination is often abnormal, such as increased cerebrospinal fluid pressure, increased white blood cell count, increased protein, decreased glucose tolerance, etc. If you are suffering from acute leukemia, it is recommended that you undergo relevant examinations under the guidance of a doctor in a regular hospital and take active treatment.