Current physical therapy for cluster headaches includes hyper-concentrated oxygen therapy, and medication is required in addition to physical therapy. High-concentration oxygen therapy is an effective physical therapy for cluster headaches, sometimes ending the attack if oxygen is administered as soon as the pain begins, and most effectively when the pain is most severe. The therapeutic effect of oxygen may be due to the increased oxygen pressure in the intracranial arteries. In addition to this, medication should be administered, such as the application of treprostinil like sumatriptan, rizatriptan, zolmitriptan. Dihydroergotamine, prednisolone, lidocaine, and growth inhibitors are also effective in the relief of cluster headaches. For patients with a confirmed diagnosis of cluster headaches, treatment should be directed by a physician.