If you have blisters in the middle of your lips, consider the following conditions: a. Papular urticaria, small blisters on the top of papules or pemphigus-like papules, the cause of the disease is mostly due to allergic reactions to mosquito bites, in clinical treatment, you need to take oral levocetirizine hydrochloride oral solution and compound glycopyrrolate tablets, and topical application of pimecrolimus ointment mixed with black bean distillate oil. The reason for this is that the immunity of the body is reduced and the herpes simplex type I virus infection is caused, so the treatment requires oral famciclovir tablets or acyclovir tablets and topical ganciclovir ointment or penciclovir ointment to kill the virus.