The etiology and pathogenesis of Henoch-Schönlein purpura are not clear, and may be related to infection, environment, heredity, and other factors, not excepting that it is related to immunocompromise. 1. Henochromatosis purpura is mostly considered to be related to infections, immune disorders, heredity and other factors, but it is not caused by immunocompromise. Usually, patients with pathogenic infections such as bacterial or viral infections may be induced to allergic purpura. The frequent use of cephalosporin antibiotics or salicylic acid, quinine, thiazide diuretics, etc. may also trigger the allergic purpura. 2. At the same time, the allergic purpura is also related to the human leukocyte antigen gene, angiotensin-converting enzyme gene, familial Mediterranean gene, mannose-binding lectin gene, vascular endothelial growth factor gene, etc., and the poor diet, environment, personal, biological and other factors, will increase the risk of the occurrence of the allergic purpura. It is recommended that patients with purpura should find out the cause of the disease under the guidance of a doctor in time, and according to the cause of the disease, take reasonable therapeutic measures under the guidance of a physician, so as to avoid delay or aggravation of the disease.