Syphilis is a sexually transmitted disease caused by the infection of the syphilis spirochete. Syphilis is a sexually transmitted disease caused by syphilis spirochete infection, which can be categorized into stage 1 syphilis, stage 2 syphilis and stage 3 syphilis according to its clinical manifestations. 1. Stage I syphilis: the main manifestation is the hard chancre, which starts as a single painless papule and rapidly develops into a superficial painless ulcer, occurring on the glans, the coronary groove, the labia, the perianal area and other parts of the body. 2. Second-stage syphilis: most patients can appear in the whole body, macular rash, maculopapular rash, some patients can also appear worm-like alopecia, bone and joints can appear osteochondritis, arthritis and so on. 3. Stage III syphilis: usually occurs 2 years after the infection of syphilis, due to the early syphilis untreated or inadequate treatment, about one-third of the patients will appear in the third stage of syphilis symptoms. In this stage, the main manifestations are nodular damage to the skin and mucous membranes, syphilitic dendritic swelling, vascular syphilis, neurosyphilis and so on. After suspecting syphilis infection, you should seek medical treatment in time, early diagnosis, early treatment, standardized course of treatment, and adequate dosage, so as not to delay the condition.