Extremely large impetigo is a common purulent skin disease with the characteristics of contact infection and autologous inoculation infection, which is mainly caused by Staphylococcus aureus, Streptococcus b hemolyticus and other infections, and it can be treated by general treatment and medication (Mupirocin) under the guidance of doctors. 1. General treatment: when patients have large impetigo, they need to pay attention to personal hygiene, keep the skin clean, and at the same time, they should be properly isolated, and the contact clothes and household items should be sterilized. 2. medication: pustules unbroken can be used externally with glycerine lotion, lesions less exudate, can be directly sterilized with alcohol, while the local use of mupirocin ointment, fusidic acid cream or compound polymyxin B and other antibiotic ointment for treatment. If necessary, oral cephalosporin antibiotic treatment. It is recommended that patients go to the hospital in time, under the diagnosis of the doctor, according to the patient’s condition, to take targeted treatment, life should pay attention to do not scratch, pay attention to diet and personal hygiene.