Thickening of the liver parenchyma is a liver imaging finding that suggests the presence of hepatic fatty infiltration or hepatic fibrosis, which in turn results in increased echo impedance of the liver, which is manifested as a thickening of the liver parenchyma on ultrasound. When the ultrasound probe scans the parenchyma, the diagnostic information on the ultrasound machine is based on the different echo impedance of the organ, which may be enhanced, coarsened, or hypoechoic. Coarsening echoes are commonly seen in fatty infiltration of the liver, fatty liver, and hepatic fibrosis following hepatocellular necrosis, all of which can lead to coarsening of liver spots. For the physiological changes of hepatocellular calcification, the appearance of calcified foci may also be manifested as strong light clusters, i.e., thickened light spots. Clinical should be combined with the patient’s liver function analysis, liver function normal can take dynamic observation method, liver function abnormalities need to carry out the next step of treatment, clear disease etiology, standardized treatment.