(Disclaimer: This article is for scientific use only. To protect patient privacy, relevant information in the following content has been processed) Abstract: This case refers to a 52-year-old male patient with densely arranged flesh-colored papules on the skin surface of the face that were not painful or itchy, and individual papules could be palpated underneath the skin as deep in nodules, but lasted relatively long and exuded fluid when broken. After consultation, the patient was diagnosed with sweat adenoma based on symptoms and pathological examination, and was treated with CO2 laser. The patient’s skin surface pustules subsided after treatment. Although the patient was wearing a mask, he could see some flesh-colored, densely arranged papules on his face through the uncovered area. According to the patient’s self-report, the densely arranged papules had appeared on his face for more than 10 years. On examination, the patient was found to have densely arranged translucent papules of 1mm-3mm in size on the face, with occasional blue faintly stained areas, and scattered hyperpigmentation on the face in patches. Individual papules can be palpated as deep-lying nodules beneath the skin. Patients report no pain or itching, and when the surface is touched with the hand, changes of a raised nature can be palpable. Small uneven dots can be seen on the surface of the patient’s nails, with loss of surface luster. The hair was in a sparse state and was considered to be a sweat gland tumor based on the patient’s overall condition. After initial communication with the patient, the patient agreed to undergo pathological examination. The pathology revealed a single cystic lumen lined with two layers of cuboidal epithelial cells within the specimen. The cystic wall of the specimen was dominated by papilloma-like hyperplasia, and the pathology supported the diagnosis of sweat adenoma. The pathology was taken at a site 1 cm lateral to the nose on the right side of the face. Local iodophor disinfection and lidocaine infiltration anesthesia were performed. A 0.3×0.5 cm sized specimen was taken with a sharp knife, and the intact vesicles were kept inside the skin. After the specimen was taken, local pressure was applied to stop the bleeding, followed by one local stitch with a No. 6 silk suture. Afterwards, the specimen was disinfected with iodophor solution and aseptically wrapped with gauze. The patient was instructed to remove the stitches in 7 days. After the pathological results showed a clear diagnosis, the patient decided to opt for CO2 laser treatment after communication with the patient. Lidocaine gel was applied to the local skin damage surface for epidermal anesthesia, and after 30 minutes, carbon dioxide laser treatment was performed to completely vaporize the vesicles raised on the skin surface by the carbon dioxide laser for the purpose of treatment. The treatment effect The sweat gland tumor itself belongs to a kind of raised skin surface change, after choosing to use carbon dioxide laser treatment once, all the vesicles on the skin surface will be completely vaporized to achieve the treatment purpose. The skin surface was restored to a complete and smooth appearance after the local disposal marks were completely healed. After 7 days of post-operative call-back, the patient indicated that the skin gradually returned to a healthy state, and the skin completely recovered, and the raised papules on the skin surface disappeared without pigmentation or pit residue. After the treatment, the raised papules on the skin surface of the patient have been healed, and we are glad that we can solve the patient’s problems for many years and discharge the patient safely. After discharge, the patient was instructed to avoid contact with water at the wound site and to return to the clinic for medication changes on the first, third and fifth postoperative days. After the local stitches are removed, a crust will form on the wound site, so do not tear it off by hand to avoid affecting the healing of the skin. After the carbon dioxide laser treatment, the local skin surface will form depressed wounds, and should not be exposed to water for 7 days, and wait until the epidermis is crusted before cleaning the face. After the surgery, a light diet, no spicy and stimulating food, seafood and fishy hair food, to avoid affecting the wound healing, after surgery may be in a place of recurrence, can return to the clinic for secondary treatment. The actual sweat gland tumor itself is a family hereditary disease, which is caused by abnormal skin keratin chromosomes. The disease is most common in young people, mainly between the ages of 15-35, but can also occur in middle-aged and elderly people. This disease can be treated with carbon dioxide laser or pulsed fuel laser to make the skin damage gradually fade away, but recurrent changes may occur later due to the body’s constitution. When sweat glands appear on the surface of the skin, it is important not to scratch frequently with your hands to avoid localized breakage and bacterial growth, which can aggravate existing symptoms and be detrimental to your health. This kind of disease is more likely to occur in the facial area, and may affect the appearance of the treatment should go to the regular hospital to choose the regular doctor for treatment.