HIV blocking medication can be taken for 28 days to test, while it is generally recommended to test 3-6 weeks after the end of the course of treatment. AIDS is an infectious disease caused by the HIV virus. Patients can be tested after 28 days of taking HIV blocking medication. In addition, it is generally recommended that patients be tested at an interval of 3-6 weeks after 28 days of taking AIDS blocking medication to review HIV antibodies and determine whether the patient’s body is infected by the virus. Secondly, to be on the safe side, it is still necessary to test for HIV antibodies 12 weeks and 6 months after the end of high-risk exposure, and if the result is still negative, the possibility of infection can basically be ruled out. In conclusion, it is necessary to do a good job of personal protection in daily life, avoid high-risk sex, strengthen the management of daily life, pay attention to personal hygiene, and do not share household goods with others.