Normal aminotransferase alpha-fetoprotein is too high, which may be caused by physiological factors such as pregnancy, or pathological factors such as fetal neural tube malformation and malignant tumors. 1. physiological factors: such as pregnant women, serum alpha-fetoprotein level will be high and normal aminotransferase, in which the level of alpha-fetoprotein will increase with the increase of pregnancy, this phenomenon belongs to the physiological increase of alpha-fetoprotein. 2. Pathologic factors: (1) fetal abnormality: if the alpha-fetoprotein is obviously elevated during pregnancy, higher than the normal range, it may suggest the existence of preeclampsia, fetal neural tube malformation, anencephaly, spina bifida, intrauterine fetal death and other diseases. (2) Malignant tumors: excessively high alpha-fetoprotein and normal transaminase can be seen in testicular cancer, ovarian cancer, teratoma, gastric cancer, pancreatic cancer and other malignant neoplastic diseases. Transaminase normal alpha-fetoprotein is too high, it is recommended that patients seek timely medical attention to clarify the diagnosis, under the guidance of the doctor for targeted treatment.