The causes of medial knee pain are more common, including knee trauma, soft tissue infection, knee osteoarthritis, etc. It is necessary to define the cause of the disease, and then give general treatment (rest, etc.), physical therapy (cold or hot compresses, etc.), drug therapy (ibuprofen, etc.) and surgical treatment for the cause of the disease. 1. Knee trauma: there is a clear history of knee trauma, which can be the injury of medial collateral ligament and medial meniscus. In the acute stage, it is necessary to reduce the activities of the knee joint and give local cold compresses, while in the relieving stage, it is possible to have proper activities and give local hot compresses; when the pain is severe, pain relieving drugs such as ibuprofen can be given to treat the pain; for the serious cases of medial collateral ligament rupture or meniscus injury, surgical repair can be given to treat the pain. 2. Knee joint infection: common bacterial infection of the soft tissue of the inner side of the knee joint, mildly give cephalosporins, levofloxacin and other antibacterial drugs to fight infection, while for serious infection, abscess formation, it is necessary to give surgical incision and drainage. 3. Knee arthritis: the more common osteoarthritis, rheumatoid arthritis, gouty arthritis, etc., for the condition of the relevant drugs can be given to the treatment, such as ibuprofen and other non-steroidal anti-inflammatory drugs, prednisone and other glucocorticosteroid drugs, gouty arthritis in the acute phase of the use of colchicine treatment, remission to give the allopurinol uric acid-lowering drugs and so on. It is recommended that patients go to the hospital, clear the cause of the disease, treatment by a professional physician, the drugs also need to be used under the guidance of a professional physician.