Initial manifestation of bone metastasis of prostate cancer is usually not obvious, and after a certain period of time, it can be manifested as prostate-related symptoms, bone-related events and systemic non-specific symptoms. 1. Prostate-related symptoms: there is no specificity, similar to the symptoms of prostatitis, which can be manifested as frequent urination, urinary urgency, increased nocturia, difficulty in urination, and so on, and in serious cases, there can be hematuria, hematospermia and other symptoms. 2. Bone-related events: Bone metastases occur in the pelvis, spine, and proximal long bones, and may manifest as bone pain, spinal cord compression, pathological fracture, anemia, hypercalcemia, and other bone-related events, which seriously reduces the quality of life of the patients, and increases the economic burden and mortality of the patients. 3. Systemic non-specific symptoms: patients with bone metastasis are prone to fatigue, emaciation, weakness and other symptoms. It is recommended to go to regular hospitals in time when the above symptoms occur, to conduct relevant examinations, to clarify the cause of the disease and then take appropriate treatment according to the staging, so as to avoid the deterioration of the disease.