The warmth of the soles of the feet of middle-aged and old people may be caused by poor ventilation of shoes and socks, diabetic peripheral neuropathy, perimenopausal syndrome, etc., which need to be treated with medication for the causes. 1. Poor breathability of shoes and socks: middle-aged and old people wear shoes and socks with poor breathability for a long time, which leads to poor ventilation of the feet and increase of local temperature, so the soles of the feet will be hot. Just pay attention to wearing shoes and socks with good ventilation. 2. Diabetic peripheral neuropathy: long-term high blood sugar level patients due to oxidative stress damage caused by peripheral nerve dysfunction, so the soles of the feet will be hot, numbness, tingling and other abnormal sensations. You can take metformin, glimepiride and other drugs or subcutaneous injection of insulin to lower sugar treatment, with methylcobalamin, lipoic acid and other drugs to nourish the nerves. 3. Perimenopausal syndrome: middle-aged and elderly women in this period of physiological decline in ovarian function, estrogen synthesis is insufficient, resulting in skin capillary diastolic disorders, so the soles of the feet will be hot, you can take methylcobalamin, glutamine and other treatments. If you exclude the improper wearing of shoes and socks and other non-disease factors, the persistence of fever on the soles of the feet, you need to go to the hospital in a timely manner to improve the relevant examination, to clarify the cause of the disease, and then timely treatment.