Many studies both nationally and internationally have now demonstrated that offspring of Alzheimer’s patients have a greater chance of developing the disease, with the incidence in close relatives of Alzheimer’s patients being more than four times that of the general population. One type of Alzheimer’s disease is reported to be called Hatton’s chorea, a rare single autosomal display genetic disorder. Half of the children and grandchildren of patients with this disease develop the disease, and the display rate of all generations is almost 100%, and no generation is spared. There are also case reports in China of up to 10 people in a family line of three generations suffering from this disease. Obviously, Alzheimer’s disease is closely related to genetics, but this is only a small part of Alzheimer’s disease, and not all Alzheimer’s disease has such a close relationship with genetics. At present, the mode of inheritance is still not very clear. Some say it is dominantly inherited; others say it is recessively inherited; others say it is polygenic autosomal recessive, and that the genetic effect can be constrained by environmental factors and mutations in genetic factors, or it may interrupt its genetic effect. Of course, there are some studies that suggest that Alzheimer’s is not a genetic disease, such as vascular dementia, which is not directly related to heredity. From a genetic point of view, Alzheimer’s disease can be divided into familial dementia and sporadic dementia. Familial dementia usually develops at an early age, around 50 years old, and is autosomal dominant, which is a relatively rare type. The genes that are now recognized to be associated with Alzheimer’s disease include progerin-2 (SP-2) on chromosome 1, progerin-1 (SP-1) on chromosome 14, and the amyloid precursor protein gene (APP) on chromosome 21, and it is believed that Alzheimer’s disease is caused by mutations in these genes. This familial dementia is typically passed down through generations in families, with about half of each generation developing Alzheimer’s disease. The other majority of Alzheimer’s disease is sporadic dementia. Sporadic dementia is a disease that is not passed down from generation to generation in the family, but the incidence is still higher in older adults with sporadic dementia than in older adults without sporadic dementia in the family, and is generally 3-4 times higher. Thus, it appears that genetics still has some influence on the onset of sporadic dementia.