Grandma Wang, 78 years old, accompanied by her family members, went to the Memory Clinic of the hospital due to gradual memory loss for 4~5 years, getting lost, not recognizing her family members, personality change and inability to take care of herself. After the doctor inquired about the medical history, clinical laboratory tests and brain CT and other tests, a clear diagnosis of Alzheimer’s disease (commonly known as dementia). When it comes to the treatment, the doctor is somewhat helpless, first of all, the dementia of Wang’s grandmother is more serious, the treatment effect is not good; then, despite the wide variety of therapeutic drugs, no less than dozens of kinds of traditional Chinese medicines and western medicines, but the efficacy of the main cholinesterase inhibitors and other kinds of drugs, mainly symptomatic treatment, the drug on cognitive function (memory, language, etc.), life function and mental behavioral symptoms have some improvement, but can not curb the disease’s Progression. Under the existing conditions, what should be paid attention to in the treatment? Early diagnosis and treatment It is currently believed that for mild to moderate dementia patients, standardized treatment can slow down disease progression, maintain life functions and reduce the burden on caregivers. Therefore, elderly people with obvious memory problems should seek medical consultation as early as possible, and be diagnosed and prescribed medication by professional doctors; 2. Suitable medication The recommended medications are two types of cholinesterase inhibitors and N-methyl-D-aspartate antagonists, the former including donepezil, sarcosine-A, lisdexamfetamine, and galantamine, which are mainly used for mild and moderate patients; the latter, also known as memantine, which is mainly used for patients with moderate to severe disease. Other drugs are also used clinically or in combination; 3. Dosage and treatment Alzheimer’s is a progressive disease, and treatment is also a long-term endeavor, usually requiring continuous medication for at least 3 to 6 months after the therapeutic dose of the drug has been reached. The safety and efficacy of the drugs should be assessed regularly, and the most important observation is adverse reactions, such as gastrointestinal discomfort common to cholinesterase inhibitors, which are generally mild and gradually tolerated. Efficacy is the biggest problem with these drugs, and patients often have questions about how they don’t improve even after taking the medication. Indeed, the treatment of dementia can not be immediate, the degree of improvement is limited, but it is certain that standardized treatment can benefit, so should adhere to the treatment. It can be seen that dementia patients should seek medical treatment as early as possible, choose the appropriate drugs and standardized treatment, which can slow down the development of the disease and improve the quality of life of patients. (To be continued)