Some patients with advanced cancer are in pain. If brain metastases appear, some will have headaches, dizziness, and severe nausea and vomiting, and some may also have seizures or even coma. If bone metastasis occurs, the pain is usually more severe. If the metastasis is in the thoracic or lumbar spine, some of them may cause paralysis, thus making the patient bedridden for a long time and unable to take care of himself. In the case of cervical metastasis, it may also cause paraplegia. If there is a tumor in the lung or mediastinal lymph node metastasis, some advanced patients will have difficulty in breathing, chest tightness, breath-holding, coughing and coughing sputum are more serious. If there is a tumor in the abdominal cavity, some of them will also cause intestinal obstruction, which will lead to nausea, vomiting, abdominal distension, and also cannot ventilate or defecate, and the patient will be in great pain.