Neurofibromatosis may develop in childhood or in the 20s and 30s. Neurofibromatosis is a neurological skin disease characterized by tumors of the nervous system and skin, and commonly subtyped as type 1 and type 2 neurofibromatosis. type 1 is more common to develop in children, and type 2 develops mostly around 20 years old. The specific analysis is as follows: 1.Type 1: In type 1 neurofibromatosis, most children present with central nervous system abnormalities, such as cognitive deficits, learning disabilities, etc., or pathologic fracture is detected when young children try to walk, and a few of them are also detected due to sensory, motor dysfunction. The main clinical manifestations are café au lait milk spots, axillary or inguinal freckles, iris malformations and neurofibromas. 2.2 Type 2: Patients with type 2 neurofibromatosis usually present with tumor-related symptoms at the age of 20-30 years. The most common intracranial tumors are vestibular nerve sheath tumors, which are usually involved bilaterally, manifesting as tinnitus and sensory neural hearing loss; followed by meningiomas, manifesting as epilepsy and headache. Cutaneous features are uncommon compared to type 1 neurofibromatosis. Both type 1 and type 2 neurofibromatosis are inherited in an autosomal dominant manner, and treatment is by clinical monitoring and timely medical intervention. If there is a family history of associated genetic disorders, early monitoring and early treatment is recommended. In addition, 50% of patients have spontaneous genetic mutations. If children are found to have behavioral disorders or other manifestations of the disease, early consultation is recommended. If there is any physical discomfort, it is recommended that the patient seek medical attention in time to avoid delays.