The etiology of Guillain-Barré syndrome has not been clearly defined and may be related to Campylobacter jejuni infection, viral infection, and immunosuppressive states. It is an autoimmune-mediated peripheral neuropathy, which is currently believed to be caused by foreign pathogenic factors that stimulate the body’s immune system to produce antibodies, which leads to an immune response against one’s own tissues, causing nerve damage. The main manifestations are symmetrical weakness, numbness and pain in the limbs. 1. Campylobacter jejuni infection: In patients with diarrhea before the onset of the disease, the infection rate of Campylobacter jejuni is 85%. Patients tend to develop the disease after the diarrhea stops. 2. Viral infections: such as cytomegalovirus, EBV, varicella-zoster virus, HIV infection, etc. 3. Immunosuppression: long-term use of immunosuppressive drugs, immunocompromised or bone marrow transplant recipients are prone to this disease. In addition, surgery, trauma, ganglioside drugs and vaccination may also be related to the development of this disease. When symptoms of numbness, pain and weakness of limbs appear or Guillain-Barré syndrome is suspected, it is necessary to consult a doctor in time to make a clear diagnosis and avoid aggravation of the disease.