Domestic Tenofovir is more effective and can play a role in treating diseases. Tenofovir has an antiviral effect, which can interfere with the replication of DNA, thus avoiding the synthesis of viral genetic material and playing an antiviral role. It has a certain effect on the treatment of chronic hepatitis B and AIDS, etc. Moreover, the efficiency of antiviral is very strong and the drug resistance rate is very low, which is suitable for long-term use by patients. Tenofovir has no cross-resistance with entecavir, telbivudine and lamivudine. If the treatment of these three drugs is ineffective or resistant, patients can use tenofovir reasonably under the guidance of the doctor for treatment. If used for the treatment of AIDS, it can be used in combination with other antiviral drugs, but care must be taken not to apply it together with drugs containing the main ingredient of tenofovir, so as to avoid duplication of medication. Tenofovir should also be used without the use of nephrotoxic drugs, so as not to aggravate the burden on the kidneys. Tenofovir belongs to the prescription drugs, it is recommended to follow the doctor’s instructions to take, avoid blindly take on their own.