In case of high urine protein in physical examination, we should first distinguish whether it is a physiological or pathological cause. If it is pathological proteinuria, 24-hour urine protein quantification should be improved, and a series of tests such as antinuclear antibody profile and virus-related tests should also be improved to rule out the possibility of secondary nephritis. If there are no clear secondary factors, primary nephritis is considered to be the cause. If the urine protein quantification is not very high (<1 gram), perindopril, Irbesartan, or Huangkui capsule can be applied to lower the urine protein; if it is high, or even nephrotic syndrome, further renal aspiration biopsy is needed to clarify the pathological type, and if necessary, hormones or even immunosuppressive drugs should be given for treatment.