The first step before treatment for a high clotting time is to identify the type of cause of the high clotting time. If it is a congenital coagulation factor deficiency that leads to a prolonged clotting time, treatment may entail treatment with coagulation factor replacement. Coagulation is improved by transfusion of certain clotting factors. If there are secondary causes of prolonged clotting time, such as those caused by certain medications, normalization can be achieved by stopping the use of such medications. There is also a category due to certain diseases, such as common liver cancer, cirrhosis patients, due to coagulation factor generation disorder, resulting in prolonged prothrombin time. In addition to the comprehensive treatment of the primary disease, it is necessary to infuse fresh frozen plasma, coagulation factors to give replacement, and then correct the abnormal coagulation function, restore normal prothrombin time.