Polygenic inheritance is a disease caused by two or more pairs of genes carrying certain factors in the human body, controlled by multiple pairs of non-allelic genes. The emergence of polygenic genetic diseases is greatly linked to the environment, compared to monogenic genetic diseases, in addition to the influence of genetic factors, but also largely influenced by the surrounding environment, showing a familial inheritance, common cleft lip and palate, from a medical point of view is an autosomal recessive polygenic diseases, schizophrenia is also one of the common diseases of polygenic inheritance, family heritability is significantly higher than other ordinary people. Chronic urticaria is also one of the polygenic genetic disorders, manifesting as genetic allergies, and exposure to allergens can lead to itchy skin, fatigue, and cough.