There is no absolute contraindication between vitamin B₆ and folic acid, can be taken together, with the effect of treating vomiting during pregnancy and other diseases, but need to pay attention to contraindications and adverse reactions. 1. Indications: Vitamin B₆ and folic acid together, can be used for vitamin B₆ deficiency, seborrheic dermatitis, vomiting in pregnancy, folic acid deficiency, folic acid deficiency caused by various reasons and folic acid deficiency caused by megaloblastic anemia, chronic hemolytic anemia caused by folic acid deficiency. 2. Adverse reactions: In the course of taking the medicine, adverse reactions such as abdominal distension, sensory abnormalities such as numbness of the extremities, motor disorders such as unsteady gait, etc. may occur, and it is necessary to discontinue use of the medicine and consult a doctor. 3. Precautions: Megaloblastic anemia due to vitamin B₁₂ deficiency cannot be treated with folic acid alone. 4. Contraindications: Hypersensitivity to vitamin B₆ and folic acid drugs is prohibited. Vitamin B₆ and folic acid need to be used under the guidance of the clinician, unauthorized use of drugs is prohibited.