Gonorrheal prostatitis can be treated with medications such as ceftriaxone, cefotaxime, and if chlamydial infection cannot be ruled out, doxycycline should also be added. Gonorrhea is caused by infection with Neisseria gonorrhoeae (gonococcus), a sexually transmitted disease that is mainly characterized by purulent inflammation of the mucous membranes of the genitourinary system. The most common manifestation in men is urethritis, and local complications can include epididymitis, seminal vesiculitis, and prostatitis. Patients usually have a history of unsafe sex, multiple sex partners or sexually transmitted infections, or a history of close contact with patients with gonorrhea. Treatment is usually with ceftriaxone or cefotaxime intramuscularly or intravenously. If chlamydial infection cannot be ruled out, treatment with doxycycline is added. Patients with gonorrhea should be treated under medical supervision.