The cost of immunotherapy for esophageal cancer is affected by many factors, with the cost ranging from thousands of dollars to tens of thousands of dollars per month for patients. Immunotherapy for esophageal cancer is determined by the patient’s physical condition, prior treatment plan and the current condition of the tumor. The cost will vary greatly depending on the immunologic drugs chosen. Taking PD-1 as an example, at present, the annual treatment cost of PD-1 in China is about 40,000 to 50,000 yuan, and it belongs to the scope of reimbursement of medical insurance in some areas, so that patients need to bear a smaller proportion of out-of-pocket expenses. In addition, the price difference between domestic and imported immune drugs is relatively large, the specific cost of the situation can consult the relevant doctors. Immunotherapy also has side effects, such as skin rash, immune pneumonia, nausea, vomiting, bone marrow suppression and so on. Therefore, if esophageal cancer patients need immunotherapy, please make sure to use it under the guidance of doctor.