Norfloxacin should be taken before meals, for people with serious gastrointestinal reactions, it is recommended to take after meals, while attention should be paid to ensure adequate water intake during the medication. Norfloxacin is an antibacterial drug that should be taken on an empty stomach to help the gastrointestinal tract absorb the drug, so it is generally better to take it before meals. However, since the drug is prone to cause gastrointestinal reactions, as well as a variety of other discomforts, it is recommended that people with severe gastrointestinal reactions take it after meals to avoid strong discomfort. In addition, large doses of norfloxacin are prone to cause crystalluria, it is recommended to drink more water during the period of taking the drug to promote urination and avoid the production of crystalluria. When there is discomfort in the body, you should actively seek medical treatment, avoid self-medication, so as not to lead to drug abuse. If serious discomfort occurs after using the medication, you should inform your doctor in time and change the medication if necessary.