The causes of stomach discomfort at night include dietary and disease causes. The treatment includes dietary adjustment and medication, and common medications include omeprazole, domperidone, and compound digestive enzymes. 1. Dietary causes and treatment: such as eating stimulating food, eating too much, lying down after eating, etc., need to adjust the diet structure, eating habits, moderate exercise, maintain emotional stability, etc.. 2. Disease causes and treatment. Such as duodenal ulcer, functional gastrointestinal disease, stomach swelling, etc., mostly need medication. Such as acid reflux, stomach pain can choose omeprazole, rabeprazole and other drugs; such as nausea, hiccups can choose domperidone, mosapride and other drugs; such as belching (hiccups), loss of appetite can choose compound digestive enzymes, mitochondrial pancreatic enzyme tablets and other drugs. For the treatment of stomach discomfort at night, it is recommended to consult a doctor to guide the treatment according to the individual situation, and take the medication as prescribed by the doctor.