Prednisone and methylcobalamin, there is no contraindication to the combined use of these two drugs, can be taken together after meeting their indications and excluding relevant contraindications to the use of the drug. Prednisone is a kind of glucocorticoid, suitable for the treatment of allergic and autoimmune inflammatory diseases, but this drug is prohibited for its allergy or the existence of hypertension, thrombosis and other diseases, the use of the drug process may be complicated by infection, peptic ulcer and other adverse reactions. Methylcobalamin, on the other hand, is a neurotrophic drug, suitable for the treatment of peripheral neuropathy, and is contraindicated in people who are allergic to it, with adverse reactions including vomiting and skin rashes. At present, there is no study suggesting that prednisone and methylcobalamin will interfere with each other’s therapeutic effect after taking them together, therefore, from the principle of drug use, as long as the user meets the indications of the two drugs and excludes the contraindications mentioned above, it is possible to take the two drugs together. However, it should be noted that the effect of drugs on the body and the impact of individual differences can exist, therefore, prednisone and methylcobalamin combined demand, must be under the guidance of the doctor to standardize the use of medication, and closely observe the effect of the drug after taking and response, if there is an abnormality need to be promptly sought medical treatment. Do not blindly use the drug or increase or decrease the dosage on your own, in order to avoid adverse consequences.