Lung adenocarcinoma without gene mutation means that patients are not applicable to targeted therapy, there is no such thing as good or bad. Lung adenocarcinoma in advanced stage is commonly treated by chemotherapy and local radiotherapy. Usually, doctors will conduct genetic test on patients, if the driver gene is positive, i.e. gene mutation, then targeted therapy can be carried out according to the gene type. Lung adenocarcinoma gene mutation is a minority of patients. Lung adenocarcinoma gene not mutated means that patients cannot use targeted drugs and can only have conventional radiotherapy. Targeted therapy refers to drugs developed against a clear cancer-causing driver gene that can specifically act on tumor cells. Lung adenocarcinoma gene not mutated is just one less treatment than mutated patients, there is no difference between good and bad. Some patients have little sensitivity to targeted drugs, and even the presence of a mutation doesn’t have much of an effect. The new immunotherapy is also more suitable for patients with lung adenocarcinoma gene not mutated. All in all, lung adenocarcinoma gene mutation or not is a disease characteristic, and the most important thing is to keep a good mindset and actively cooperate with doctors for treatment.