Waking up at 1:00 to 3:00 may be related to physiological factors, or it may be caused by neurasthenia, sleep apnea syndrome, mental disorders and other reasons. 1. Physiological factors: such as recent stress, often excessive late night, resulting in sleep rhythm is disrupted, or due to age, resulting in a large period of sleep can not be maintained, etc., may appear one to three o’clock wake up. 2. Neurasthenia: the disease is often combined with sleep disorders, which can show the situation of waking up at one to three o’clock in the middle of the night, and can be accompanied by difficulty in falling asleep, dreaming during sleep, memory loss, lack of concentration, daytime sleepiness and other manifestations. 3. Sleep apnea syndrome: patients show frequent snoring during night sleep, which can easily cause apnea, and may wake up from one to three o’clock in the morning, accompanied by sleepiness the next day, morning headache and other symptoms. 4. Mental disorders: commonly found in anxiety disorders, depression and other diseases, due to the patient’s long-term bad mood, easy to form a sleep disturbance, may appear in the middle of the night one to three o’clock wake up, can also be accompanied by slow thinking, memory loss and other symptoms. Wake up at one to three o’clock, if long-term persistence exists, it is recommended to consult a doctor as soon as possible, after diagnosing the cause of the disease, under the guidance of the doctor to deal with the symptoms.