Urea ointment is mainly used to soften and dissolve keratinized skin, and is commonly used for abnormal keratotic skin diseases such as perifollicular keratosis and ichthyosis. The main ingredient of urea ointment is urea, which can dissolve skin keratin and increase protein hydration, thus promoting the softening and dissolution of the stratum corneum. The base of urea ointment is mainly petroleum jelly, which can form an oil film on the surface of the skin, locking the skin moisture to prevent evaporation. Urea ointment is mainly used for perifollicular keratosis, ichthyosis which is an abnormal skin keratinization disorder, and can also be used as an adjunctive treatment for chronic eczema, chronic tinea versicolor, or psoriasis. It can also be used to moisturize the skin when the weather is dry. A common side effect of urea ointment is that it tends to cause localized redness and pain in the skin. Women who are breastfeeding or pregnant should use urea ointment with caution, and should consult a doctor before using the medication.